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Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

(4) Single route of administration: the current preclinical animal studies and clinical human trials predominantly employ oral administration as the primary intervention method for BBR, with a notable lack of research on alternative delivery approaches such as transdermal absorption

Nanobots are designed to traverse the BBB via multiple pathways, enabling the precise transport of drugs or nutrients into endothelial cells

Collectively, genetic alterations within the p53/MDM2/p14ARF pathway, including p53 mutations, MDM2 amplification, and p14ARF deletions, constitute major drivers of GBM pathogenesis