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Implement comprehensive metabolic phenotyping for patient stratification: Clinical trials of metabolic inhibitors should incorporate advanced metabolic characterization of tumors using multi-tracer PET imaging, hyperpolarized MRI, tissue metabolomics, and analysis of metabolic enzyme expression

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Additionally, we identify a particular cluster of intratumoral CD8+ T cells expressing a putative gene signature of GSH metabolism (GMGS) in association with clinical response and survival across several human cancers