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It significantly downregulates the expression of costimulatory molecules CD80 and CD86, as well as MHC class II, though it does not affect MHC class I expression

L., Kim, K

Neurology (2003) 61:50615.10.1212/01.WNL.0000078939.64774.1B 96 RamaekersVTSequeiraJMArtuchRBlauNTemudoTOrmazabalAet alFolate receptor autoantibodies and spinal fluid 5-methyltetrahydrofolate deficiency in Rett syndrome