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Testing also showed that the measure far exceeded the 0.4 threshold for mean reliability, which we reaffirmed as the threshold for reliability in the CY 2022 PFS final rule (86 FR 64996)

Testicular exposure to ionizing radiation and sperm epigenetic alterations as possible mechanisms of hereditary effects: perspectives from the viewpoint of radiation protection

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Monitoring Strategy Baseline (before starting): Complete pain assessment with validated tools Neurological examination Basic metabolic panel, HbA1c (if diabetic), vitamin B12, TSH INR if on warfarin Cardiovascular risk assessment Ongoing: Pain assessment every 4-8 weeks initially, then every 12 weeks INR weekly 2 weeks then monthly if on warfarin Neurological examination every 6-12 months Annual laboratory monitoring for long-term use 4