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In addition to lactate being a viable fuel source for driving hippocampal epilepsy, glycogen stored in astrocytes can be transported into neurons through the lactate shuttle and converted into lactate for fuel (Boison and Steinhauser, 2018)

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Reader beware, this is a complex topic, but nonetheless, lets dig into this a bit more, with a look at how MTHFR relates to DNA methylation and the one-carbon pathway