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Cell-intrinsic PD-L1 signaling drives immunosuppression by myeloid-derived suppressor cells through IL-6/Jak/Stat3 in PD-L1-high lung cancer

Gender Women typically have a higher liver volume per unit of lean body mass and lower water content than men

Therefore, abnormally high expression of associated membrane proteins which mediate drug efflux is one of the causes leading to chemotherapy resistance ( Figure 1 )