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These findings further support its potential as part of a comprehensive lipid-lowering strategy

101 Whereas, the classical explanation is that, while hydroxychloroquine impaired phago/lysosomal function, it also appears to work in a lysosome-independent manner by impacting on intracellular TLRs, particularly TLR9, by inhibiting the production of TNF, and by interfering with the processing of the conversion of the membrane-bound pro-TNF into soluble mature protein

Core stability work reduces compensatory strain on hip structures

To address a potential role of cell migration and cell-matrix interactions, we used the Esm1-CreERT2 line to inactivate the Itgb1 gene, which encodes the integrin 1 subunit (Fig