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Pyroptotic and non-pyroptotic effector functions of caspase-11

Previous studies report that PA induces apoptosis and reduces migration in glioblastoma cells, potentially through inhibition of the multidrug resistance protein MRP1 ( Ferroptosis represents a unique form of iron-dependent regulated cell death, biochemically characterized by depletion of GSH, functional inactivation of the key antioxidant enzyme GPX4, and consequent accumulation of toxic lipid peroxides ( Our initial bioinformatics analysis suggests a mechanistic link between PA, NSCLC, and ferroptosis ( Ferroptosis is mechanistically defined as an iron-dependent, non-apoptotic form of regulated cell death characterized by distinct morphological and molecular features

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