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Autophagy is a conserved homeostatic process in eukaryotic cells involving sequestration and lysosomal degradation of cytoplasmic contents, including damaged or surplus organelles (mitophagy for mitochondria, pexophagy for peroxisomes, ribophagy for ribosomes, reticulophagy for endoplasmic reticulum), cytotoxic macromolecular aggregates (aggrephagy), and intracellular microorganisms (xenophagy) (128131)

However, further studies are needed to explore the clinicopathologic features and implications of targeted therapy for IDH1/2-mutated CRC (Huang et al., 2021)

Larazotide is a peptide designed specifically to address intestinal permeability, commonly known as leaky gut. This condition occurs when the tight junctions in the intestinal lining loosen, allowing toxins, pathogens, and undigested food particles to escape into the bloodstream

19 , jjae137 (2025)