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The second mechanism is through the interaction between glutamate and the cystine transporter, which reduces intracellular glutathione (GSH) and increases ROS accumulation

The effect of cryopreservation on the genome of gametes and embryos: principles of cryobiology and critical appraisal of the evidence

The results indicated that GC tissues had increased levels of ATF4 as compared to normal tissues ( Figure 2A )

10.1016/j.cell.2005.06.022 Summary Keywords kinase, mitochondrial morphology, mitochondria, apoptosis, mitochondrial associated endoplasmic reticulum membranes (MAMs), reactive oxygen species (ROS), disease adaptation Citation Skalka GL, Tsakovska M and Murphy DJ (2024) Kinase signalling adaptation supports dysfunctional mitochondria in disease