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In response to light exposure, both euthymic and actively affected bipolar patients manifest two-fold greater reduction of nocturnal plasma melatonin concentrations compared with the healthy controls (181, 182, 186)

Asanuma, M., & Miyazaki, I

This is manifested by insufficient infiltration of antigen-presenting cells (APCs), which results in the failure to effectively capture DAMPs (e.g., ATP, HMGB1) released by dying tumor cells, thereby inhibiting cross-presentation of antigens and activation of cytotoxic T lymphocytes (CTLs) (82)

doi: 10.1038/ng.2901, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 47.Mancina RM, Dongiovanni P, Petta S, Pingitore P, Meroni M, Rametta R, et al