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High mobility group box 1 (HMGB1): HMGB1 is a nuclear protein that plays essential roles within the cell, such as organizing genetic material and facilitating DNA repair

358 Senescent chondrocytes induce senescence in other chondrocytes in cartilage by releasing SASP factors, such as IL-6, IL-1, and MCP1

However, as it sounds like you agree, it's pretty clear that as insulin levels go down IGFBP-3 goes up...sorry, as IGF binding protein 3 goes up...maybe it's worth me taking a moment why that matters

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