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Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities

Whilst clinically significant hypoglycaemia is uncommon in people without diabetes, those taking insulin or sulfonylureas are at considerably higher risk of low blood sugar during calorie restriction a situation that can cause palpitations, tremor, and anxiety

Recent research has identified several adaptive mechanisms through which red blood cells regulate oxygen delivery, including NO-driven changes in membrane deformability, Cys93-dependent S-nitrosylation, adenosine-mediated stimulation of glycolysis and 2,3-BPG production, and the formation of hypoxic memory via degradation of eENT1 (Peng et al., 2019

The data revealed that higher Notch1 level coincided with higher MANF level, while lower Notch1 level accompanied by lower MANF level in ICC cell lines (Supplementary Fig