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Description

Abstract Free radicals, characterized by the presence of unpaired electrons, are highly reactive species that play a significant role in human health

identified that low expression levels of ELOVL5 in breast cancer is correlated with poor prognosis because ELOVL5 can produce PUFAs that can induce ferroptosis in cancer cells [100]

In line with the importance of TXNRD1 in the regulation of ferroptosis and apoptosis in AML cells, auranofin, a TXNRD1 inhibitor, impaired cell viability in AML subtypes dependent on TXRND1 for their protection against ferroptosis [53]