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Among gastrointestinal comorbidities, a recent survey on an adult population showed that CVS was significantly associated with irritable bowel syndrome, gastroparesis, and gastroesophageal reflux

These microbial changes are correlated with fluctuations in beta diversity, which represent structural changes in the microbial community, although alpha diversity is frequently stable

Despite the complexity of TMAOs role in atherosclerosis, studies have indicated that managing TMAO through nutrition, medication, or microbiome modification may help lessen its effects and even reverse its contribution to the advancement of the disease [73, 76]