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Moreover, a randomized clinical trial in patients with advanced pancreatic carcinoma demonstrates that combination of the anti-IGF-IR mAb MK-0646 with gemcitabine is tolerable and associated with improvement in overall survival but not progression-free survival as compared with gemcitabine plus erlotinib [151]

Overall and pulmonary progressors had significantly lower survival rates than the counterparts (59.9% vs

Although the mechanism underlying the augmented excitatory neuronal tone in autism is yet to be clarified, several lines of evidence support that astrocytes are involved in the modulation of the neuronal excitability in central nervous system diseases 21,22 , as astrocytes are involved in the regulation of Glu, Gln, and GABA levels in the brain 23

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