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reassess the person shortly before the prescription ends Study evidence shows that among men and women from diverse racial and ethnic groups, quitting smoking was associated with large reductions in the excess mortality associated with continued smoking (4) all-cause mortality rate ratio (RR) for current vs never smoking was 2.80 overall when comparing those who quit smoking before age 45 years with never-smokers, all-cause mortality RRs were 1.15 A systematic review stated that (5): most effective interventions were nicotine e-cigarettes, varenicline and cytisine found high-certainty evidence that when compared to control, nicotine e-cigarettes, varenicline and cytisine might lead to an additional eight (95% CrI 4-13), eight (6-10) and seven (4-12) additional quitters per 100, respectively Reference: British Heart Foundation, Factfile 6/99

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This increases the risk of heart disease, much like clogging up the pipes in your home plumbing system.