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Titration of Otezla/Otezla XR is intended to reduce the gastrointestinal symptoms associated with initiation of therapy 1 For pediatric patients with severe renal impairment: 1, , For initial dosage titration, it is recommended that Otezla be titrated using only the AM schedule shown above for appropriate body weight category and that the PM doses be skipped

Oral contraceptives: May lower serum vitamin B12 concentrations (34)

This is the kind of flexibility thats crucial in a lab setting