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Oliver Sartor discussing the ARTISIAN trial, a phase 1/2 dose escalation and expansion trial of AB001 in patients with metastatic castration-resistant prostate cancer (mCRPC)

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The importance of a good segmentation becomes apparent in the subsequent quantification steps

In our study, the ACTH levels might have possibly increased more gradually after the activation of the HPA-axis in response to the psychological stressor, and this might have resulted in a delayed feedback and therefore a longer cortisol response compared to physiological validation studies