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These results revealed an antioxidant effect through Nrf2-mediated HO-1 induction

M.KouretasD.VeskoukisA.et al (2019a)

It is metabolised into cyclohexamine, which is thought to be responsible for the carcinogenic effect of cyclamate, 78 an effect that resulted in the banning of cyclamate in the UK and the US, although this toxicity is still controvertial

KRAS mutations in pancreatic cancer cells rely on both endogenous TNF -related apoptosis-inducing ligands (TRAILs) as well as their receptors to promote tumor growth and metastasis ( KRAS mutations evaded immune therapy by upregulating programmed cell death 1 ligand 1 (PD-L1) transcription and protein expression ( KRAS mutation could also enhance the recycling of PD-L1 molecules in pancreatic cancer cells to the cell surface to promote the immune escape of pancreatic cancer cells ( KRAS mutation-containing PDAC tumors displayed high m6A scores, suggesting a correlation between KRAS , m6A, and immune escape (Figure 7)