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Week 2: Early responders may notice reduced morning stiffness or slightly less pain during aggravating activities

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They came in louder over the last twelve months, and louder still in the last few weeks

Numerous clinical trials have verified the significant promise of c-MET inhibitors when used alongside ICIs, with several such trials currently in progress (Table 2) [141]

This lack of delay would represent a major advantage if translatable to humans, given that conventional antidepressants typically require 2-6 weeks before patients experience relief