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Verni et al., 2019)

This provides a rationale for nanoplatforms that reduce excitotoxic signaling or protect vulnerable neurons [126]

The authors emphasize the different physiopathological aspects of portal hypertension in sarcoidosis: healing fibrosis, large sarcoid granulomas and small perigranular arteriovenous shunts may increase sinusoidal resistance leading to portal hypertension

In both current studies, the safety data with cagrilintide were consistent with data from previous studies with no new safety or tolerability issues observed [4, 7, 10]