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storage at ambient temperature in darkness is recommended Precautions & Notes Stability may be affected by light, heat, and extreme pH Experimental outcomes depend on concentration, model system, and formulation Appropriate controls are recommended for enzymatic and cellular assays Intended strictly for laboratory research use

27 Differentiated from migraine by its side-locked pain and agitation, cluster headaches are typically shorter (averaging 90 minutes) and typically exhibit circadian (classically one to two hours after sleep onset) and circannual periodicity (bouts occur at the same time of year, typically in autumn and spring)

10.1152/ajpheart.00986.2004 10 BeutlerE

Myopathy with lactic acidosis is linked to chromosome 12q23.324.11 and caused by an intron mutation in the ISCU gene resulting in a splicing defect