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ALS is recognised as a multisystem neurodegenerative disorder, meaning that many patients also show non-motor symptoms including executive, behavioural and speech issues

So that further targeted research to understand the exact reason of RLS should get focused

Notably, certain plant-derived metabolites activate neuroprotective signaling pathways, such as the MAPK/NF-B system, (Md et al., 2021), and interact with estrogen receptor beta (ER), a known regulator of synaptic plasticity and neuroprotection ( 4.6 Overcoming challenges in translating natural compounds into clinical applications Despite promising findings, translating the therapeutic potential of natural compounds into clinical practice presents several key challenges

Most ototoxic drugs have at least additive ototoxic interactions