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53 Tubular epithelial cells are particularly susceptible to glucose-induced metabolic derangements

In vitiligo patients, melanocytes are particularly sensitive to oxidative damage, which disrupts TYR function, inhibits eumelanin synthesis, and ultimately impairs pigmentation 46

In the same way, Hu and colleagues 19 showed that admission levels of PCT could also help in outlining the disease severity and death in hospitalized COVID-19 patients

For example, a therapeutic approach of activating the GCN2 pathway and increasing antioxidant capacity of T cells may be prudent in the PDAC environment, where oxidative and metabolic stress is high, but may not work for other tumor microenvironments that dont share the same stress, such as lymphoma and melanoma