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doi: 10.1016/j.cell.2018.05.003 74 Del PradoL.Jaraz-RodrguezM.AgroM.Zamora-DortaM.AzpiazuN.CallejaM.et al

Oxaliplatin, another platinum drug, induces tumor cell apoptosis by forming DNA adducts and triggers ICD

The development of highly selective and structurally optimized CYP51A1 inhibitorsor context-specific modulatorscould provide valuable therapeutic strategies, particularly in hormone-sensitive cancers, immune regulation, and metabolic diseases