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Those documents often reveal the agencys specific safety and impurity concerns

Warfarin: The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone

The cytoprotective role of Sp was further evaluated through determination of mitochondrial function and amount of intracellular lipid peroxides quantified by measuring the levels of their decomposed carbonyl product malondialdehyde