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Finally, the novel nitrogen-containing metabolites (R) -gentiandiol (RG) and (S) -gentiandiol (SG) were detected in rats after oral administation of STM using LC-MS and then synthesized from STM for the first time (Figure 1)

The increase in MG after H 2 O 2 stimulation may be significantly associated with increased glycolysis

HSCs, the primary producers of ECM, play an indispensable role in the pathogenesis of liver fibrosis ( The pathogenesis of liver fibrosis is complex, with sustained HSC activation and ECM deposition due to chronic liver injury being major contributors ( in vitro and animal models has revealed multiple pathways by which glycyrrhizin inhibits HSC activation

Snakes exhibit extreme patterns of fasting compared to other animals