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It was found that post-drug loading and HA coating led to progressive changes in surface charge towards the negative

Notably, the SNX1-SNX2 heterodimer produces heterogeneous structures, including spherical vesicles, recapitulating in vivo observations

This review has mapped their pleiotropic actionsranging from redox buffering and immune modulation to epigenetic reprogrammingand highlighted encouraging preclinical synergy with radiotherapy, chemotherapy, and immunotherapy