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Pharmacological modulation of glycinergic inhibition could represent a novel therapeutic strategy for a variety of diseases involving altered synaptic inhibition, primarily in the spinal cord and brain stem but possibly also at supraspinal sites [74]

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intravenous TB-4 Phase 1 safety and pharmacokinetics, no dose-limiting or serious adverse events (Ann N Y Acad Sci 2010;1194:223229): NCT00743769 Centers for Disease Control and Prevention