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While mutations of ETC proteins are rarely linked as a direct cause of PD (except for UQCRC1), impaired ETC proteins may not only lead to excessive ROS production, but also cause impeded mitophagy, -Syn aggregation, and apoptosis in PD pathogenesis

Phytochemicals such as CGA, berberine, ganoderic acid, costunolide, piperine, and cardamonin not only reshape microbial communities but also influence their metabolites, gut barrier function, mucosal immunity, and even central nervous system signaling

Bioinformatics 2020;36:39167

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