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72 Because of this early presentation, end-stage liver disease and development of hepatocellular malignancy may occur before the age of 1 year

doi: 10.3389/fnut.2025.1654911 Received 27 June 2025 Accepted 24 July 2025 Published 05 August 2025 Volume 12 - 2025 Edited by Pangzhen Zhang, The University of Melbourne, Australia Reviewed by Jata Shankar, Jaypee University of Information Technology, India Santino Orecchio, University of Palermo, Italy Updates Copyright 2025 Noreen, Sultan, Hashmi, Aja and Atoki

115 In VHL- mutant renal cancer, the functional output of the tumour-initiating VHLHIF2A pathway is altered in metastatic clones through NF-B-dependent co-option of specific lymphoid enhancers upstream of the chemokine receptor CXCR4

Malcolm, Institute of Terrestrial Ecology, Monks Wood Experimental Station, Huntingdon, United Kingdom ( Co-Rapporteur ) Dr M.V