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The majority of intracellular proteins are degraded by the ubiquitinproteasome system (UPS), a multi-enzyme process that involves the covalent conjugation of ubiquitin to a substrate protein and its recognition and degradation by the core multicomponent proteolytic complex of the UPS, the proteasome

Using siRNA against various forms of the G protein-coupled receptor kinase (GRK) family, DAMGO was demonstrated to phosphorylate T370 and S375 by GRK2 and 3 while morphine increases S375 phosphorylation by GRK5 (Doll et al., 2012)

elegans strains, which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440)

These findings may provide new insights into the pathophysiology and treatment of PCOS (167)