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J Evid-based Complement Altern Med

However, efficient endosomal escape and intracellular release of the active PROTAC remain important determinants of the ultimate degradation efficacy

Furthermore, reduced expression of melatonin receptor 1A (MT1) in astrocytes leads to increased pathological Ca 2+ influx, exacerbating oxidative stress and suppressing the NRF2/SLC7A11/GPX4 antioxidant axis, ultimately promoting neuronal ferroptosis (Zhang S