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[14] In hyperammonemic environments (high levels of ammonia), astroglial swelling occurs

Consequently, Arg143 interposes between disulfide bond residues Cys57 and Cys146 and greatly increases solvent accessibility of the SOD1 Cubinding site, [47] ensuring the amenability of the active site to receive Cu whilst simultaneously preventing premature disulfide bond formation

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The PHB1-ANXA2 receptor complex that FTPP targets appears on the vasculature of white fat but not brown fat