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10.1016/j.intimp.2023.110571 47 JiangL.GuY.DuY.LiuJ

(2005) 81:326S9S

Brain metabolite labelling was modelled using first-order driven kinetics to estimate the labelling dynamics of GABAH4 and GluH4 within a simplified representation of cerebral metabolism (Equations 1 and 2): Effective influx and efflux constants Glu,in = 0.86 -1 -1 , Glu,out = 0.95 -1 -1 and GABA,in = GABA,out = 0.086 -1 -1 were defined as composite fluxes including literature-based values for human brain