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Discussion Though the efficacy of cuprizone pellets has been debated 27,28 , research has proven that at more chronic timepoints cuprizone pellets can induce reliable demyelination 29,30,31,32,33,34,35

Chih-Yuan Ko, orcid.org/0000-0002-5767-3041 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

For example, a cohort study of CVD in the town of Hisayama showed that people with a reduced plasma level of GSH are at increased risk for CVD, especially for cerebral small vessel disease [130]