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While a causal relationship has not been established, patients with depression or other psychiatric conditions should be monitored for changes in mood or behavior, particularly during the initial weeks of treatment or following dose adjustments

Monitoring: A history of the patients allergies/hypersensitivity should be obtained before administering cyanocobalamin injection

Studies using dual-energy X-ray absorptiometry (DEXA) body composition analysis confirm tesofensine treatment significantly reduces total fat mass and visceral adipose tissue while maintaining skeletal muscle mass

The common starting dose in community protocols is 100 mcg per shot, once daily at bedtime, on an empty stomach, for about one week