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However, clearance can markedly affect the extent of availability because it determines the extraction ratio (equation [8a])

Methods Animals Animal experiments were performed with adherence to all national and local guidelines and regulations, the Guide for the Care and Use of Laboratory Animals 25 , and the ARRIVE guidelines, and with the approval of the Institutional Animal Care and Use Committee at The University of Texas Medical Branch (UTMB)

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While its still early in human research, the pathways it targets are well-documented in metabolic science, and the results so far are promising