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Among them, 15.5% with type 1 diabetes mellitus (T1DM) have abnormal myocardial systolic or diastolic function, whereas patients with type 2 diabetes mellitus (T2DM) are mostly middle-aged and elderly, with a relatively higher risk of cardiovascular system complications ( Ferroptosis is a new type of programmed cell death that is often accompanied by massive iron accumulation and lipid peroxidation, as well as a deficiency in oxidoreductases, especially glutathione peroxidase 4 (GPX 4 ) ( 4 directly or indirectly through different pathways, causing a decrease in cellular antioxidant capacity and accumulation of lipid reactive oxygen species (ROS), ultimately leading to cell death ( In recent years, studies have shown that ferroptosis is strongly associated with various diseases including ischemic heart disease, kidney disease, liver damage, degenerative diseases, and diabetes ( 2 Roles and regulatory mechanisms of ferroptosis 2.1 Ferroptosis and iron metabolism Iron is an important nutrient in the human body and is involved in a variety of biological processes, such as oxygen transport, lipid metabolism, DNA and protein synthesis, and cellular respiration

doi:10.15212/AMM-2022-0005 8

When a muscle is stimulated by a nerve impulse, Ca2+ is released from the sarcoplasmic reticulum into the cytoplasm of the muscle fiber

GHK-Cu is the specific tripeptide with the most clinical backing