Several independent studies have also shown that treatment with arimoclomol, a co-inducer of heat shock proteins, is protective against toxic mutant SOD1 aggregates, delays disease progression and improves motor function in SOD1 G93A mice (Kieran et al., 2004

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[Abstract]2020 Oct 23;6(43):eaba4147
Regenerative strategies that have garnered much interest in recent years are focused on elucidating the native developmental processes of the IVD to apply early developmental signals for in vivo tissue regeneration by combining tissue engineering using biomimetic scaffolds, targeted drug delivery for endogenous cell activation and differentiation, and exogenous cell implantation (Pirvu et al., 2014