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While iron and transferrin have been shown to induce hepatic stellate cell activation and collagen expression in vitro [86,87,88], in vivo models of iron overload demonstrate only minor fibrosis, although the numbers of alpha-smooth muscle actin (SMA)-positive myofibroblasts were significantly increased [89, 90]

A review found selenium supplements in daily dosages of 100300 mcg led to improved thyroid function at 6 months in people with Graves disease, but this effect was lost at 9 months (34)