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GDNPs significantly suppressed IL-4/IL-13-induced M2-like polarization, as evidenced by downregulation of M2 markers such as CD206 and reduced expression of M2-related genes, while enhancing secretion of M1-associated cytokines, including TNF-, IL-12, and IL-6, suggesting a Th1-biased immune environment favorable for CD8 T-cell activation

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