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Clearance of a drug is the factor that predicts the rate of elimination in relation to the drug concentration (C): Clearance, like volume of distribution, may be defined with respect to blood (CL b ), plasma (CL p ), or unbound in water (CL u ), depending on where and how the concentration is measured

Growth hormone and insulin-like growth factor I treatment increase testicular luteinizing hormone receptors and steroidogenic responsiveness of growth hormone deficient dwarf mice