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NETs present a sticky extracellular scaffold composed of DNA, histones, and neutrophil proteases that bind von Willebrand factor (vWF), trap platelets, and promote fibrin deposition, thereby accelerating thrombus growth and conferring resistance to fibrinolysis [65]

Key benefits and findings include: Antioxidant Action: PLE reduces oxidative stress, a critical factor in melasma, by neutralizing free radicals and minimizing UV-induced inflammation

S7a) and the intracellular GSH content (Supplementary Fig

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