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Alcohol consumption can increase brain oxidative stress through various mechanisms, mainly due to its metabolism by CYP2E1 enzyme and the subsequent production of ROS ( Mitochondrial uncoupling protein 2 (UCP2) is an anion transporter located in the inner mitochondrial membrane ( UCP2 gene is located on chromosome 11 (11q13) ( UCP2 variant is the missense variant rs660339 in exon 4, a C to T transition, resulting in an amino acid substitution at position 55 of the UCP2 (Ala55Val) which seems to modify the uncoupling degree and consequently protein activity ( UCP2 variants may be tissue depended ( UCP2 rs660339 variant with migraine susceptibility and clinical phenotypes

Pathogenesis of hyperadrenergic orthostatic hypotension

4c) and the resulting assembloids closely mirrored the cellular composition and proportions of tissue (Fig

Bioinformatics 31 , 12431249 (2015)