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Research in skin cultures has suggested that GHK may stimulate the synthesis as well as the breaking down of collagen, glycosaminoglycans, and other components of the skins extracellular matrix like proteoglycans and chondroitin sulfate

Beyond LCs, 1,25(OH)D also modulates dermal CD14 dendritic cells (dDCs), enhancing their CCR7-mediated migration and partial activation without promoting inflammatory cytokine release, and instead favoring the induction of IL-10 Tr1-type Tregs [142]