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For example, the following options may be used: antithyroid drugs (methimazole and propylthiouracil), radioactive iodine, beta-blockers, and surgery (Wiersinga et al

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Similarly, alcohol metabolism by CYP2E1 enzyme generates reactive oxygen species including hydrogen peroxide (H2O2), superoxide and hydroxyl radicals which have important roles in causing damage to DNA and in fatty acid oxidation

Indeed, recent widely based studies carried out in Europe (the MICONOS (Mitochondrial Protection with Idebenone in Cardiac Or Neurological Outcome Study) trial, comprising 232 patients with 162 on idebenone, mostly adults, at 13 centres