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Six to eight month old C57BL/6 mice were injected with 400,000 B 16-F10 cells in 200 PBS by tail vein injection and subsequently received daily intraperitoneal injections of either D-Nle-X-Cys-NH-(CH 2 ) 5 -CONH 2 (10 Mg/kg and 100pg/kg) or a PBS vehicle control

Long-term insomnia is not only a risk factor for the incidence of T2DM [6] but also worsens glycemic control [7] and increases the risk of dementia [8], depression [9], and cardiovascular diseases such as hypertension, myocardial infarction, and stroke in T2DM [10]

Therefore, the ICH S6(R1) guideline would not be applicable to current MSPs