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Notably, 4-HNE can activate the PPAR pathway, suppressing PGC-1-mediated mitochondrial biogenesis and reducing local ATP supply at synapses, thereby impairing plasticity mechanisms such as LTP (56) Simultaneously, the electrophilic properties of 4-HNE facilitate its formation of adducts with synaptic proteins (e.g., synapsin I, PSD-95), directly disrupting synaptic ultrastructure (194)

According to some researchers, garlic might reduce insulin resistance, blood sugar, and cholesterol levels in patients with diabetes

Anise (Pimpinella anisum) The spice plant anise has similar properties to fennel